Hand in Hand (2007)

The story, told in real time, is that of a young couple, Cate and Wes, in NYC who have quarantined themselves during a smallpox breakout. As time passes the couple begins to break under the pressure and the flaws of their relationship become exposed. The films dialog heavy, emotionally character driven story follows the life cycle of an entire relationship in one night from fights to sex to heartache and finally to a resolution.