Fu Manchu (Christopher Lee)

Grisly strangulations in London alert Nayland Smith of Scotland Yard to the possibility of the fiendish Fu Manchu may not be dead after all, even though Smith witnessed his execution. A killer spray made from Tibetan berries seems to be involved and clues keep leading back to the Thames.

Fu Manchu and his army of henchmen are kidnapping the daughters of prominent scientists and taking them to his remote island headquarters. Instead of asking for ransom, Fu demands that the fathers help him to build a death ray, which he intends to use to take over the world. But Fu's archenemy, Sir Denis Nayland Smith of Scotland Yard, is determined not to let that happen.

Fu Manchu replaces his arch-nemesis Nayland Smith with a hypnotized, murderous doppelgänger as part of a plan to become leader of the world's criminals.

Fu Manchu is hidden with his evil daughter Lin Tang in a lost city he has found in the jungles of South America. He discovers a poison deadly for men through kiss and he abducts ten women to infect them with the poison to destroy his enemies. Then he sends one woman to London to kiss his greatest enemy, the Scotland Yard agent Nayland Smith. Nayland is blinded by the poison and his friend Dr. Petrie travels with him to the jungles in South America to seek out Fu Manchu expecting to find an antidote. They team up with agent Carl Jansen and soon they learn the scheme of Fu Manchu for world domination.

The evil mastermind Fu Manchu plots his latest scheme to basically freeze over the Earth's oceans with his diabolical new device. Opposing him is his arch-nemesis, Interpol's very British Dr. Nayland Smith.