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Brian Finch, a struggling musician, unlocks his brain's full potential with the new drug NZT-48, letting him become the smartest person alive for twelve hours. Teaming up with FBI Agent Rebecca Harris and aided by Senator Morra's immunity shot, Brian solves cases while navigating the dangerous world of espionage and deception. As he uncovers NZT's dark secrets, Brian faces moral dilemmas and personal challenges, determined to use his abilities for good.