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As a prison riot erupts into violence, Red comes face to face with the ring leader: the man who once held him hostage and nearly drove him mad. Injured prisoners are moved to a crumbling, overstretched hospital. But what they don't know is a killer's amongst them, preying on their weaknesses. As the vicious murders spiral out of control, can Red and his team put aside their own emotional torment and find a method in his madness?