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When a puzzling airplane accident claims the lives of all passengers and crew during an international flight, FBI agent Olivia Dunham uncovers a former scientist held in a psychiatric facility who may hold key information. Teaming up with Walter Bishop, the scientist, and his son, Peter, they delve into a web of inexplicable occurrences, including genetic anomalies, resurrections, and parallel dimensions. Unbeknownst to them, they're about to unravel a complex series of events that could alter the course of existence as we know it.