Some moments involve unexpected close calls. In one episode, Link almost hits Chase with a dart as he throws it on a whim and Chase happens to be moving towards the target location at the moment. In a blooper, a severe chemical reaction results in an unexpected explosion due to Rhett adding an excess of a component, and Rhett and Link run off unscathed.
In one episode, Link is sat down while thousands of bees crawl up his torso and onto his face - they cover his entire face and attempt to pry his mouth open. This episode is not for the squeamish, especially those with a phobia of bees and/or trypophobia. However Link comes out with only one or two stings.
Rhett and Link often participate in challenges, such as eating the world's hottest chillis, eating bugs, sitting in an ice bath and holding their breath underwater. Their suffering can be quite intense, especially in the case of the chillis and the ice bath. However, it is all done for laughs and they are always OK at the end.