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Renowned oneirologist Ambrose London is requested to appear at Arkham Asylum by newly appointed Dr. Barnard to study the strange case of James Fhelleps. A patient seemingly inhabited by the personality of Joe Slater, a denizen of the Catskill Mountain region and a primitive colonial peasant of barbaric degeneracy, who had mysteriously vanished 122 years ago. Ambrose and Barnard's investigation takes an unexpected turn when Fhelleps/Slater is attached to London's Dream Machine that releases an alien life from Hell bent on world annihilation.