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Tom and Mary are two siblings who, after being orphaned, travel to the United States in search of their uncle Niall. They sneak onto a train traveling to California with a group of orphans, and meet Nick, a boy with cerebral palsy. Getting off the train to touch some buffalo, the three children miss the transport, which is then taken over by a band of outlaws. With the help of an indigenous tribe, they must help the passengers as they continue their search for a new home.