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The Guide tells the story of Danny, a young Mohawk man struggling to adjust to a life threatening condition that forces to him make strict food and lifestyle choices. But Danny just wants to be normal and refuses to listen to the warnings of his doctor, loved ones, and a spiritual visitor in his dreams. Will his rebellious state of mind blind him to the wisdom his culture is offering and the love of woman who has his best interest at heart? Danny has less time than he thinks to realize what is important and make the changes he needs to survive.