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Carolina and Bernabé decide to separate after 15 years of marriage, just as the world faces the pandemic and social confinement. The problem is that Bernabé is a hypochondriac epidemiologist who will soon return home, as his only refuge. While Carolina, a successful businesswoman, will have to face the complications of a mandatory quarantine, and learn to be the mother of her two children: Macarena and Marcelo.