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A psychologist, Ethan Bishop, interviews a, "Jane Doe." The film's majority takes place inside a single room, at a interrogation table, and concerns Ethan's psycho analysis for the FBi. A politician, Governor Larson, was killed with a needle full of air but the needle was found in the trash without any other pieces of physical evidence. The FBI are desperate for answers because they can only legally hold her for ten more hours. The film cuts between Ethan's race against time to get answers from Jane and flashbacks which reveals information about her first kill and her subsequent murders.