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Malignant Humor tells the story of ERIN, RYAN, JACK, and GABI, four friends in an improv group, who get the worst gig ever. Booked to perform at a high school after a major tragedy, the team struggles with the line between humor and heart. The ringleader of the group, Erin, who uses humor as a defense mechanism, must learn to let her guard down when shit gets real, or else risk losing those she cares about; be it KAT, her younger sister, who is still freshly coping with loss, or her improv team, who she soon discovers she doesn't know as well as she once thought she did. When nothing else is funny, Erin and her friends turn to comedy as a way to cope.