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When her husband goes missing, underappreciated suburban homemaker Sue Buttons (Allison Janney) gets a taste of being a local celebrity as she embarks on a city-wide search of Yuba County to find him. Trying to prolong her newfound fame, she stumbles into hilarious hijinks as her world turns upside-down: dodging a wannabe mobster (Awkwafina), a relentless local policewoman (Regina Hall), her local news-reporter half-sister (Mila Kunis) who's desperate for a story, and her husband's deadbeat brother (Jimmi Simpson), who all set out to uncover the truth behind the disappearance.