Stuck with Each Other (1989)

Two luckless New Yorkers, a salesman (Richard Crenna) and a secretary (Tyne Daly), report to the office one morning to discover that their boss has dropped dead--leaving behind an open safe containing $964,000 that he isn't supposed to have. They divide the illicit funds between them and are immediately pursued by two thick-eared thugs (Michael J. Pollard, Bubba Smith). For the rest of the film, Crenna and Daly are reluctantly paired as a united front against the bad guys.