Ripper 2: Letter from Within (2004)

The director of an asylum offers to the serial killer Molly Keller a chance to be submitted to a pilot unconventional experiment in Prague, in the Weisser Institute. Molly accepts, and she travels to the clinic, where Dr. Samuel Wiesser developed a treatment using a virtual world, and Molly and deranged youngsters would be trial subjects. However, something does not work well in the experiment, and when the patients die in their trip, the same happens in the real world. The explanation is a huge twist point in the very end of the story.