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Two years after the desperate attempt to eradicate the snake-head menace in Maryland's once-serene Cultus Lake, the fish population continues to decline. However, as if that weren't enough, someone thought that it would be a great idea to fill the lake with potent growth hormones to increase the lake fisheries, resulting in the creation of a mutated strain of more powerful and more ferocious aquatic predators. Now, Sheriff Patrick James and the marine biologist, Lori Dale, have to right a wrong, before the now-uncontrollable monsters decimate the entire community. Do they have what it takes to stop the snake-head terror?