Duane Incarnate (2004)

Gwen, Connie, Fran, and Wanda are best friends, high on life. Well, not Wanda. She's the least beautiful one, with the least interesting personality, who's lost her job, and who's always getting dumped by men. But then she meets Duane, the most wonderful man in the world, and he's madly in love with her. He's handsome, successful etc. The other girls don't get it. And then things get weird. Somehow, Duane's attraction to Wanda has thrown the whole world off-track. Can they end their friend's relationship with Mr. Wonderful before it's too late?