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The tale opens with the election of Rodriga Borgia to the office of Pope Alexander VI. Then it switches to a succession of attempts by Caesar Borgia to kill or have killed Alfonzo of Aragon, husband of Lucretia. The assassinations are attempted while Lucretia, who constantly watches over her weak spouse, is away at various affairs of state and social life. While she is attending a banquet, Alfonzo is finally stabbed by one of Caesar's lieutenants. It is discovered that Lucretia's husband has been murdered under the direction of Caesar, which inflames the people to revolt, and the despot is overthrown and himself killed by the mob.