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In Mumbai, Rizwan Khan, a Muslim with Asperger's syndrome, a high-functioning autism, marries Mandira, a Hindu single mother, in San Francisco. Post 9/11, he faces a misunderstanding due to his condition. Detained, he befriends therapist Radha, who aids him in coping with his predicament. Motivated to meet President Bush and clear his name, Rizwan embarks on a poignant journey navigating societal perceptions and personal struggles.