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Hilary Swank stars as American interior-designer Mary and Brenda Blethyn stars as British homemaker Martha, two women who have little in common--apart from the one thing they wish they didn't. When malaria strikes, the lives of these very different women change forever. They forge a deep friendship and embark on an epic journey of self-discovery to Africa, dedicating themselves to the cause of malaria prevention. Beginning to rebuild their lives, they show how ordinary people can make a difference and inspire positive change in the process. Enlisting the help of Mary's estranged father, a former politico, the two women beseech both the powers that be and ordinary people to get involved, realizing a shared responsibility to all the world's children.