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A college athlete, Nate Lyles has had roles in theater performances to television, working with major TV networks, from Starz to FX, in primetime TV shows, as well as widely broadcasted commercials. Lyles has starred in a now popular subject, COVID-19 PSA commercial, as well as playing a supporting role in the hit show Power: Book 2. He is also seen in the primetime TV show Pose, season 2 and Broad City on Comedy Central network, in addition, the very first theatrical production of Mud Row by Dominique Morisseau.