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Jayne McLendon was born in Delaware and lived with her family in Texas, California, England, and Kuala Lumpur, Malaysia. She began acting at the Country Playhouse in Houston, TX, and later at Abbey Gate College in Chester, England and The Laguna Playhouse. When she was 18 she moved to New York City to attend NYU's Tisch School of the Arts, where she studied at the Lee Strasberg Institute and Stonestreet Film Studios. She received her MFA in Acting from Brown University/Trinity Rep.