Tenshi ga Kieta Machi (2000)

A pair of half-brothers has been living quite distinct lives. The younger has loose ties with the underground world and maintains little contact with the family. The elder, who is autistic but highly artistic, works in a factory. After losing his job, the elder brother moves in with his younger one. Though initially negative about the new burden on his shoulders, the younger brother's heart softens toward his autistic relative. Just when things are going smoothly, the elder is diagnosed with blood cancer and needs a transfusion. A futile search for their father prompts a fallback on shady connections to raise the money for the treatment.