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Place a multi-threat performer, a variety show, a game show and a talk show into a blender, turn it on, and the resulting mixture is "Best Time Ever with Neil Patrick Harris". With the help of a different celebrity announcer every week, his regular stable of sidekicks and other celebrity friends, NPH kvetches with, plays games with and pranks studio audience members, at home viewers, and even unsuspecting people going about their regular business who have no idea that they will be on the show. He challenges his several celebrity friends to races and games, often of an extreme nature. And each show ends with a production number appropriately called the end of the show show.