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On Shackle Island, there is a somewhat dilapidated-looking mansion. And inside that mansion, there is a friendly and talkative scientist by the name of Dr. Gangrene. If you need shelter from the rain, Dr. Gangrene will be more than happy to accommodate you. Of course, if you do accept Dr. Gangrene's hospitality, you will have to visit the laboratory and take a look at the doctor's truly impressive collection of brains.