There is one scene at the beginning where Sienna gets bullied, she was pushed to the floor and runs out crying.
Throughout the movie, there can be slapping, pushing, and other physical contact throughout.
In the chase scene, Olivia Bell shoots Mandy on the hand, and she cries. A few seconds later, Mandy runs into the bathroom just to see the blood on her hands, and she vomits.
Jay makes a new invention where everyone don't feel pain or blood, and he tests it on Caleb by stabbing, slapping and shooting him, but he turns out alright.
In one scene, Annie says to Principal Crunch that Sienna has tripped over and she has a really deep cut and she could see her bone.
James falls out a window trying to save the Mighty Six, but he ends up in a body cast.