No explicit nudity, some discussion about sex, but nothing major.
Violence & Gore
None
None.
Profanity
Severe
Frequent strong language.
"Fuck" is said 40 times, "Shit" is said 14 times. "Dick" is said 17 times and "pussy" is said once. The slur "faggot" is said 9 times in one skit. "Goddamn" and "Jesus" are both used once.
Alcohol, Drugs & Smoking
Mild
There is an act where Bo Burnham mimes making a peanut-butter & Jelly sandwich while high on marijuana, and while drunk. It is played for laughs, as is mostly everything in the show.
Frightening & Intense Scenes
None
There is a song titled "Kill Yourself," which can be taken as offensive and intense in some circles.