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In 1899, recent graduate Dr. Edward Newgate arrives at Stonehearst Asylum, eager to begin his residency in asylum medicine. He is introduced to the enigmatic superintendent, Dr. Silas Lamb, who employs disturbing, "revolutionary" methods. Edward grows uneasy, especially after meeting Eliza Graves, a compelling patient who insists she is sane and warns him of unseen dangers. Driven by infatuation and a sense of duty, Edward sets to discover the truth.