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Deniz Isin was born on 28 May 1992 in Izmir. She graduated with a bachelor's degree in chemical engineering from Ege University and got her master's degree in materials science and engineering from the same university. She then took acting lessons for two years at Sahnetozu Theatre in Izmir and later spent a year studying acting in Istanbul. In 2017, she took part in an adaptation of Lysistrata, and in the following year she portrayed Alice in You Can't Take It with You. She attracted attention with her videos she have posted on the Scorp Platform. After appearing in a number of TV commercials, Isin made her television debut with FOX's Her Yerde Sen. She then had a supporting role on Iyi Günde Kötü Günde before rising to prominence with her role as Sahra in Sefirin Kizi. Additionally, Isin was featured in the music video for Murat Boz's song "Gece". She became well known with her portrayal of the character Irem in the TV series Masumiyet. She had leading role in action film "Anka Kusu" and comedy film "Ask Cagirirsa Gelir". She was chosen for iconic role "Leyla" in hit surreal comedy series Leyla ile Mecnun came back after 8 years. It is fifth lead role "Leyla", which played by different actresses. She wrote and played in short comedy series "Eee Sonra"/"Bizden Olur Mu" which published in Youtube and later Blutv. She played in short film "Oluler Icin Yasam Kilavuzu", which premiered in Cannes Film Festival. She is playing in series "Sevmek Zamani".