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Mark Garcia was born and raised in Harlingen, Texas. His parents, Dr. Gregorio Garcia and Diana Garcia, are both educators. He graduated from Texas A&M University with a Bachelor of Science in Biology. He completed medical school at the University of Texas Medical Branch at Galveston, Texas. He completed a residency in Pediatrics at the University of Texas Health Science Center at San Antonio and fellowship in Pediatric Hematology/Oncology at UCLA. As of 2022, he is a fellow in Pediatric Bone Marrow Transplant at Boston Children's Hospital. He was a principle actor in the Season 18 finale of Grey's Anatomy, where he played the role of a Pediatrician.