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Jefe the Entertainer was born in Baltimore, Maryland, the third of five children of Juanita (Lang), and Isaac Loyal, Sr. He grew up in a lower class area in Baltimore City. Isaac attended the Baltimore Talent Development High School located in on the west section of Baltimore, Maryland. He got the nickname "Jefe The Entertainer" because of the way he could charm his audience in any performing setting. After a successful career as both a radio (Online Radio) and television (Comcast) personality, Isaac's curiosity in acting emerged after he was casted for several local commercials. He has starred in BET's original series entitled "Criminals at Work".