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Seishiro Tokai (Kazunari Ninomiya) works as a surgeon at a university hospital. He possesses excellent technique with suture and carries a surgery success rate of 100%. Due to his arrogant attitude and personality, he comes into conflict with those around him. A new doctor tries to introduce the latest medical device for surgery, which doesn't need a surgeon's hand. Seishiro Tokai is skeptical of the device. He faces the university hospital administration and reveals corruption and hidden past behind the medical device.
Two corrupt cops murder an undercover DEA agent by mistake, and frantically try to cover their tracks by framing a homeless man for the crime. That involves juggling evidence, coaching witnesses, and improvising to keep their desperate scheme from unraveling.
A surgeon discovers that he can restore the beauty to his girlfriend's scarred face by murdering other women and extracting fluids from their pituitary gland. However, the effects only last for a short time, so he has to kill more and more women. It is ultimately a killing spree which ends with considerable death and disaster.
Joe Carol Brain attempts to hire Dr. Black Jack on a breed of superhumans that have the strength, intellectual, athletic, and artistic skills with great excel in different fields, only to later find out that they start deteriorating after some period of time and causing an untimely death. Joe needs Dr. Black Jack's help on finding a cure.
Two pretty but ditsy American girls are on a road trip through Europe. In Germany, they end up alone at night with a broken car in the woods. They search for help and find an isolated villa. The next day, they awaken to find themselves trapped in a terrifying makeshift basement hospital along with a Japanese man. An older German man identifies himself as a retired surgeon specialized in separating Siamese twins. However, his three "patients" are not about to be separated but joined together in a horrific operation. He plans to be the first person to connect people via their gastric systems. By doing so, he plans to bring to life his sick lifetime fantasy, the human centipede.
Fictional webtoon entitled W is written by its legendary author Oh Seong-moo which begins to function on its own, like a different world existing there. The story-line of the webtoon starts when a handsome and intelligent boy Kang Chul becomes famous as he won a shooting competition. But this fame is interrupted when the unknown Murderer massacres his family, and he is erroneously accused of the crime. Yeon-joo is the daughter of the author of the famous W. She goes to her father's studio to investigate his sudden disappearance. There, she is pulled into W's alternate universe and meets its protagonist Kang Chul with whom she eventually falls in love.
A look at the professional and personal lives of the staff at New York's Knickerbocker Hospital during the early part of the nineteenth century. Every day they must deal with lack of funding, personal conflicts, egotism, racial tensions, personal vices, drug addiction, affairs, closed minds, dated nigh-medieval medical techniques and them and their experimental new techniques being misunderstood by most, in order to keep the hospital going and give the ill the help they need. The pressure is enormous and leaves its mark on the souls of most of them.